Prostaglandin Receptor (PG Receptor)

Prostaglandin receptors, also known as prostanoid receptors, are a subfamily of G protein-coupled receptors (GPCRs) that mediate the actions of prostanoids—bioactive lipids derived from arachidonic acid. There are eight main types/subtypes of human prostaglandin receptors: EP1, EP2, EP3, EP4 (for PGE₂); DP1 (for PGD₂); FP (for PGF₂α); IP (for PGI₂); and TP (for thromboxane A₂). These receptors are widely distributed throughout the body and regulate diverse physiological processes, including inflammation, vascular tone, platelet aggregation, and smooth muscle function. They are implicated in various disease states and are targeted by NSAIDs and other drugs.

Other names

Prostanoid ReceptorPGD2 receptorPGE2 receptorPGF2α receptorPGI2 receptorThromboxane A2 receptorDP1 receptorDP2 receptorEP1 receptorEP2 receptorEP3 receptorEP4 receptorFP receptorIP receptorTP receptor

Agonism or antagonism of prostaglandin receptors leading to downstream effects on cAMP, calcium signaling, and other cellular processes.