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Target intelligence / Profile preview
Prostaglandin reductase 1 (PTGR1)
- Target
- PTGR1
- Molecular classification
- Enzyme, Oxidoreductase, Alkenal/one oxidoreductase (AOR)
01
Overview
Prostaglandin reductase 1 (PTGR1) is an NADPH-dependent alkenal/one oxidoreductase that plays a central role in the metabolic detoxification of alkenals and ketones, particularly medium-chain compounds. It is a rate-limiting enzyme in arachidonic acid metabolism, deactivating eicosanoids like prostaglandins and leukotriene B4. PTGR1 is involved in cell proliferation and cancer biology, with altered expression affecting tumor metabolism and progression. It also participates in drug metabolism, activating certain prodrugs. Due to its diverse roles, PTGR1 is being investigated as a potential therapeutic target for cancer and other diseases.
- Other names
- LTB4DHZADH3
02
Mechanism of action
Reduction of α/β-unsaturated carbonyl compounds, activation of prodrugs, deactivation of eicosanoids
03
Biological functions
Eicosanoid catabolism/detoxificationCell proliferationDrug metabolismArachidonic acid metabolism regulation
04
Disease associations
CancerThoracic ossification of the ligamentum flavum
05
Safety considerations
Context-dependent oncogenic or tumor-suppressive roles require careful consideration for therapeutic targeting.Potential for off-target effects due to broad substrate specificity.
06
Interacting drugs
CS-670
1 more in the full profile.
07
Biomarkers
PTGR1 expression levels in cancer tissues (prognostic marker)
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