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Prostaglandin reductase 1 pseudogene (LOC100130018; ENSG00000213226) is a segment of the human genome that resembles the functional prostaglandin reductase 1 (PTGR1) gene but does not encode a functional protein. Pseudogenes are nonfunctional DNA sequences, often resulting from duplication or retrotransposition of functional genes, but they typically lack regulatory elements required for expression or contain disabling mutations. This particular pseudogene is not implicated in disease, has no known biological activity, and should not be confused with the active PTGR1 enzyme—the latter does play roles in eicosanoid metabolism and disease pathology.
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