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Target intelligence / Profile preview
Prostaglandin reductase 3 (PTGR3)
- Target
- PTGR3
- Molecular classification
- Enzyme
01
Overview
Prostaglandin reductase 3 (PTGR3) is a protein coding enzyme that acts as a 15-oxo-prostaglandin 13-reductase, catalyzing reduction of 15-keto prostaglandins such as 15-keto-PGE1 and 15-keto-PGE2 (with highest efficiency toward 15-keto-PGE2-alpha). It is localized predominantly in mitochondria. PTGR3 is involved in the negative regulation of fat cell (adipocyte) differentiation, possibly through repression of PPARG transcriptional activity. Dysregulation of PTGR3 has been associated with developmental disorders and may play roles in metabolic processes.
- Other names
- ZADH2PRG-3MGC45594PTGR-3Zinc-binding alcohol dehydrogenase domain-containing protein 2PTGR3prostaglandin reductase-3zinc binding alcohol dehydrogenase domain containing 2zinc-binding alcohol dehydrogenase domain-containing protein 2
02
Biological functions
15-oxo-prostaglandin 13-reductase activityNegative regulation of fat cell differentiation
03
Disease associations
Musculoskeletal diseases (e.g., Vertical talus, Congenital)Schwartz-Jampel syndrome, Type 1Putative metabolic and adipogenesis roles (based on functional associations)
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