Prostaglandin Synthesis (Central)

Prostaglandin synthesis (central) refers to the enzymatic process by which prostaglandins, a group of bioactive lipid mediators, are produced from arachidonic acid within cells, particularly within the central nervous system. This pathway is central to the regulation of inflammation, pain signaling, vascular tone, and other physiological processes. Key enzymes involved include phospholipase A2, cyclooxygenases (COX-1 and COX-2), and various terminal synthases that produce specific prostanoids like PGE2, PGD2, PGF2α, PGI2, and TXA2. Prostanoids exert their effects through specific G protein-coupled receptors (GPCRs).

Cyclooxygenase (COX) inhibition