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Target intelligence / Profile preview
Prostaglandin Synthesis Enzymes (PGSE)
- Target
- PGSE
- Molecular classification
- Enzyme, Cyclooxygenase, Synthase, Isomerase
01
Overview
Prostaglandin synthesis enzymes, primarily cyclooxygenases (COX), are a group of enzymes responsible for the biosynthesis of prostaglandins from arachidonic acid. These enzymes play a critical role in inflammation, pain, and various other physiological processes. Inhibition of COX enzymes is the mechanism of action for many nonsteroidal anti-inflammatory drugs (NSAIDs).
- Other names
- Cyclooxygenase (COX)Prostaglandin SynthaseProstaglandin H Synthase (PGHS)COX-1/PTGS1COX-2/PTGS2Prostaglandin D Synthase (PGDS)Prostaglandin E Synthase (PGES)Prostaglandin F Synthase (PGFS)Prostacyclin Synthase (PGIS)Thromboxane A Synthase (TXAS)
02
Mechanism of action
Inhibition of cyclooxygenase activity, leading to reduced prostaglandin production.
03
Biological functions
Prostaglandin synthesisInflammation mediationPain signalingRegulation of blood flowProtection of gastric mucosaPlatelet aggregation
04
Disease associations
InflammationPainCardiovascular diseaseGastrointestinal disorders
05
Safety considerations
Gastrointestinal bleedingCardiovascular eventsRenal dysfunction
06
Interacting drugs
NSAIDs (e.g., Ibuprofen, Aspirin, Celecoxib)
1 more in the full profile.
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