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Prostaglandin Synthesis Pathway
- Molecular classification
- Pathway, Enzymatic Pathway
01
Overview
The prostaglandin synthesis pathway refers to the series of biochemical reactions that convert membrane phospholipids into prostaglandins, a group of lipid compounds with diverse physiological roles including inflammation, pain signaling, and regulation of blood flow. This pathway is present in nearly all nucleated cells and is tightly regulated due to the potent biological effects of its products. Key enzymes include Phospholipase A2 (PLA2), Cyclooxygenases (COX-1/2), and various terminal synthases. Products include prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), and thromboxane A2 (TXA2). The pathway is targeted by NSAIDs and steroidal anti-inflammatories.
02
Mechanism of action
Inhibition of cyclooxygenase (COX) enzymes, inhibition of phospholipase A2 (PLA2)
03
Biological functions
InflammationPain signalingRegulation of blood flowAutocrine/paracrine signalingVascular tone regulationPlatelet aggregationUterine contraction
04
Disease associations
InflammationPainCardiovascular diseaseCancer
05
Safety considerations
Gastrointestinal issues (NSAIDs)Cardiovascular risks (NSAIDs)Increased risk of infection (Steroids)
06
Interacting drugs
Aspirin
3 more in the full profile.
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