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Prostaglandin Synthesis Pathway Enzymes
- Molecular classification
- Enzyme
01
Overview
Prostaglandin synthesis pathway enzymes are a group of enzymes responsible for the biosynthesis of prostaglandins, which are lipid mediators involved in inflammation, pain, fever regulation, vascular tone, and reproductive processes. These enzymes catalyze the conversion of arachidonic acid (released from membrane phospholipids) into various prostaglandins and related compounds through a series of enzymatic steps.
- Other names
- Prostanoid Synthesis EnzymesEicosanoid Synthesis Enzymes
02
Mechanism of action
NSAIDs inhibit cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis.
03
Biological functions
Prostaglandin synthesisInflammationPain perceptionFever regulationVascular tone regulationReproductive processes
04
Disease associations
InflammationArthritisCardiovascular diseaseCancerMenstrual disordersAsthmaAllergy
05
Safety considerations
Gastrointestinal side effects (NSAIDs)Cardiovascular risks (selective COX-2 inhibitors)
06
Interacting drugs
Aspirin
2 more in the full profile.
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