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Prostamide Receptor (None)

Target: None
Molecular classification: G protein-coupled receptor (putative), Receptor (putative)

Overview

The prostamide receptor is a putative G protein-coupled receptor that binds prostamides, a class of lipid-like substances related to prostaglandins. While pharmacological evidence supports its existence and distinct properties from classical prostanoid receptors, it has not yet been cloned or structurally characterized. It is implicated in the regulation of intraocular pressure and may play roles in inflammation and pain.

Other names: Prostamide F2α receptorPutative prostamide receptor

Mechanism of action

Antagonism of prostamide receptor (putative)

Biological functions

Regulation of intraocular pressureInflammation modulation (possible)Nociception/pain signaling (possible)

Disease associations

GlaucomaInflammation (possible)Pain (possible)

Safety considerations

Lack of full molecular characterization makes prediction of off-target effects challenging.Potential for species-specific effects given limited understanding of receptor orthologs.

Interacting drugs

AGN 204396

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