Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Prostanoid EP1 Receptor (EP1)
- Target
- EP1
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The Prostanoid EP1 receptor, also known as Prostaglandin E2 receptor 1 (EP1), is a G protein-coupled receptor (GPCR) that primarily binds prostaglandin E2 (PGE2). Activation leads to stimulation of phospholipase C (PLC), resulting in increased intracellular inositol trisphosphate (IP3) and diacylglycerol (DAG), which mobilizes intracellular calcium (Ca2+). It mediates various physiological functions, including smooth muscle contraction and has been implicated in neurodegenerative diseases and cancer. Antagonists have shown efficacy in preclinical models for reducing neurotoxicity.
- Other names
- Prostaglandin E2 Receptor 1PTGER1
02
Mechanism of action
Gq protein activation, phospholipase C (PLC) stimulation, increased intracellular inositol trisphosphate (IP3) and diacylglycerol (DAG), mobilization of intracellular calcium (Ca2+)
03
Biological functions
Signal transductionSmooth muscle contractionCalcium mobilizationNeurotransmission
04
Disease associations
Neurodegenerative diseasesAlzheimer's diseaseParkinson's diseaseStrokeAmyotrophic lateral sclerosisEpilepsyCancerNeurotoxicityNeuroinflammation
05
Safety considerations
Potential for neurotoxicity via increased calcium signalingSpecies-specific differences in tissue distribution
06
Interacting drugs
ONO-8713
3 more in the full profile.
Beyond the preview
Go deeper on Prostanoid EP1 Receptor (EP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Prostanoid EP1 Receptor (EP1).