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Prostate and testis expressed protein 3 (PATE3)
- Target
- PATE3
- Molecular classification
- Secreted protein, Member of the three-finger protein (TFP)/Ly-6/uPAR family
01
Overview
Prostate and testis expressed protein 3 (PATE3) is a member of the Ly-6/uPAR/three-finger protein superfamily, characterized by a conserved arrangement of 10 cysteine residues forming a three-fingered structural motif[1][2]. It is secreted and primarily found in the male reproductive tract (prostate, testis, seminal vesicle, epididymis), and its expression is androgen-dependent[1][2]. PATE3 exhibits antimicrobial activity, likely contributing to innate immunity and defense mechanisms in the reproductive tract. It may also participate in sperm maturation and has a structure resembling certain neurotoxins (e.g., bucandin), suggesting potential neuromodulatory functions, though these roles are not fully defined[1][2][4].
- Other names
- PATE3PATE-DJHEL-127Acrosomal vesicle protein HEL-127PATE-like protein DJSecreted TFP/Ly-6/uPAR protein PATE-DJ
02
Biological functions
Antimicrobial activity (confers antibacterial defense in the male reproductive tract)Putative neuromodulatory activityPossible regulation of ion-channelsResponds to immune challenges (e.g., upregulated by lipopolysaccharide)
03
Disease associations
Currently, no established direct roles in diseaseAssociated gene (PATE3) is linked to Mal De Meleda, but direct causality/functional significance is not established
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