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Target intelligence / Profile preview
Prostate androgen-regulated mucin-like protein 1 (PARM1)
- Target
- PARM1
- Molecular classification
- Other (mucin-like type I transmembrane protein)
01
Overview
Prostate androgen-regulated mucin-like protein 1 (PARM1) is a highly glycosylated, mucin-like type I transmembrane protein predominantly localized to the Golgi apparatus, plasma membrane, and early endocytic compartments. PARM1 is expressed in several tissues, most notably in prostate, heart, kidney, and placenta, with its expression being upregulated by androgens in androgen-dependent prostate cancer cells. Experimental evidence demonstrates a role for PARM1 in promoting prostate cell proliferation and resistance to apoptosis, possibly by modulating telomerase activity. Beyond prostate biology, PARM1 is implicated in urogenital development, and decreased levels have prognostic significance in colorectal cancer, correlating with tumor aggressiveness and patient survival. No directly interacting drugs, mechanisms of action, or therapy-related safety concerns are currently documented for this target.
- Other names
- PARM-1Cipar1DKFZP564O0823WSC4Castration-induced prostatic apoptosis-related protein 1
02
Biological functions
Regulation of cell proliferationApoptosis resistance in prostate cellsDevelopmental processes in urogenital system (e.g., septation of cloaca)
03
Disease associations
Cancer (prostate cancer, colorectal cancer)Developmental malformations (e.g., epispadias)
04
Biomarkers
Prognostic biomarker in colorectal cancer (lower expression correlates with worse outcomes)
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