Prostate androgen-regulated transcript 1 (PART1)

Prostate androgen-regulated transcript 1 (PART1) is a long non-coding RNA (lncRNA) predominantly expressed in the prostate and several other tissues, initially identified due to its upregulation by androgens in prostate cancer cells[1][3]. PART1 does not encode a protein product and exists in multiple transcript forms. It plays context-dependent roles in cancer and other diseases: acting as an oncogene in some cancers (e.g., promoting proliferation, invasion, and resistance to therapy) and as a tumor suppressor in others[1][5]. PART1 mechanistically regulates cancer cell behavior by interacting with various microRNAs (such as miR-4516 and miR-937-5p) and influencing the expression of different genes relevant to tumorigenesis. Its expression patterns and functional impacts render it a potential biomarker for cancer prognosis, though it is not currently a receptor, enzyme, or direct therapeutic target[1][3][5].

Other names

PART1prostate androgen-regulated transcript 1lncRNA PART1

Not a classical target for drug action; PART1 modulates cancer-associated pathways via interaction with microRNAs and gene regulation