Prostate-associated gene 3 protein (PAGE3)

Prostate-associated gene 3 protein (PAGE3) is a member of the cancer/testis antigen family, typically expressed in a range of tumors and normally limited in expression to certain reproductive tissues. PAGE3 is not an enzyme, receptor, or transporter, but rather a non-enzymatic antigen found in various tumors, where it may play roles in cellular stress responses and the regulation of cell proliferation. Its restricted normal tissue expression and upregulation in cancer make it a potential biomarker and immunotherapeutic target for cancers, especially prostate cancer[3]. No small-molecule drugs are known to directly target PAGE3, but it is being investigated as a cancer biomarker and possible target for T-cell-based immunotherapy.

Other names

P antigen family member 3GAGED1PAGE-3CT16.6G antigen family D member 1P antigen family, member 3 (prostate associated)G antigen, family D, 1

Not established (target is not a common enzyme or receptor; function is antigenic and regulatory)