Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Prostate cancer susceptibility candidate protein 1 (PRAC1)
- Target
- PRAC1
- Molecular classification
- Other (Small nuclear protein)
01
Overview
Prostate cancer susceptibility candidate protein 1 (PRAC1) is a small nuclear protein of approximately 6 kDa, encoded by the PRAC1 gene on chromosome 17q21, located about 4 kb downstream from the HOXB13 gene. It is specifically and highly expressed in prostate, rectum, and distal colon tissues, as well as in some prostate cancer cell lines. Protein localization studies and sequence analysis suggest a regulatory function in the nucleus, potentially related to tissue-specific gene expression. Aberrant epigenetic regulation (notably DNA methylation) of PRAC1 is associated with more aggressive tumor behavior and poor prognostic features in both prostate and bladder cancers, indicating utility as a prognostic biomarker; however, it is not currently considered a therapeutic target, and no known drugs interact directly with PRAC1.
- Other names
- C17orf92PRACSmall nuclear protein PRAC1Prostate, rectum and colon expressed gene protein
02
Biological functions
Putative nuclear regulatory role
03
Disease associations
Cancer (notably prostate, bladder, and colon cancer)
04
Biomarkers
Prognostic marker in prostate cancer and nonmuscle invasive bladder cancer (by methylation and/or expression levels)
Beyond the preview
Go deeper on Prostate cancer susceptibility candidate protein 1 (PRAC1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Prostate cancer susceptibility candidate protein 1 (PRAC1).