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Target intelligence / Profile preview
Prostate Specific Antigen (PSA)
- Target
- PSA
- Molecular classification
- Protein, Glycoprotein, Serine Protease, Enzyme
01
Overview
Prostate-specific antigen (PSA) is a protein produced almost exclusively by cells of the prostate gland. It functions as an androgen-regulated serine protease enzyme and its main physiological role is to cleave semenogelins within the seminal coagulum, aiding sperm motility by liquefying seminal fluid after ejaculation. Clinically, PSA is primarily used as a biomarker for screening, diagnosis, and monitoring prostate cancer. Elevated serum PSA can also result from benign conditions such as benign prostatic hyperplasia (BPH) or prostatitis.
- Other names
- Kallikrein IIISeminaseSemenogelaseγ-seminoproteinP30 antigen
02
Mechanism of action
Inhibitors being developed; currently primarily used as a biomarker
03
Biological functions
Semen liquefaction via cleavage of semenogelins
04
Disease associations
Cancer
05
Safety considerations
OverdiagnosisOvertreatment
06
Biomarkers
Prostate cancer diagnosisProstate cancer screeningProstate cancer monitoring
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