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Target intelligence / Profile preview
Prostate stem cell antigen (PSCA)
- Target
- PSCA
- Molecular classification
- Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein
01
Overview
Prostate stem cell antigen (PSCA) is a GPI-anchored cell surface glycoprotein involved in intracellular signaling and potentially acetylcholine receptor regulation. It is overexpressed in several cancers, including prostate, bladder, pancreatic, and NSCLC, and is associated with more aggressive disease. Conversely, it is downregulated in esophageal/gastric cancers, suggesting a possible tumor-suppressive role in those contexts. Due to its restricted expression pattern and overexpression on tumor cells, PSCA is considered a potential target for immunotherapy.
02
Mechanism of action
Not applicable; PSCA itself is not a drug, but a target for therapeutic intervention such as immunotherapy or siRNA.
03
Biological functions
Intracellular signalingAcetylcholine receptor regulation (potential)
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects in immunotherapy due to expression in normal tissues (prostate, bladder, etc.)
06
Biomarkers
PSCA expression levels in prostate cancerPSCA expression levels in bladder cancerPSCA expression levels in pancreatic cancerPSCA expression levels in non-small cell lung cancerPSCA expression levels in esophageal/gastric cancers
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