Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Prostatic Acid Phosphatase
- Molecular classification
- Enzyme, Phosphatase, Protein Tyrosine Phosphatase
01
Overview
Prostatic acid phosphatase (PAP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced primarily by the epithelial cells of the prostate gland. It catalyzes the dephosphorylation of organic monophosphate esters with optimal activity at acidic pH. Elevated serum levels are primarily found in metastatic or advanced-stage prostate cancer, but can also be increased in other conditions. Recent research indicates a role in dephosphorylating ErbB-2/Neu/HER-2, impacting tumorigenicity and androgen sensitivity. Measurement of serum PAP aids prognosis assessment for prostate cancer patients.
- Other names
- ACP3PSAPTM-PAPACP-3Acid phosphatase 3ACPP
02
Mechanism of action
Dephosphorylation of target proteins, including ErbB-2/Neu/HER-2
03
Biological functions
DephosphorylationSemen liquefactionPhosphate metabolismRegulation of tumorigenicityRegulation of androgen sensitivity
04
Disease associations
Prostate cancerTesticular cancerLeukemiaNon-Hodgkin's lymphomaBone diseases (Paget’s disease, hyperparathyroidism)Sickle-cell diseaseMultiple myelomaLysosomal storage diseases (Gaucher’s disease)
05
Safety considerations
Non-malignant factors can affect serum levels (gland manipulation, medications)Limited specificity as a tumor marker compared to PSA
06
Biomarkers
Elevated serum PAP levels in advanced/metastatic prostate cancerPrognosis assessment for prostate cancer patientsPrediction of recurrence after radical prostatectomy
Beyond the preview
Go deeper on Prostatic Acid Phosphatase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Prostatic Acid Phosphatase.