Target intelligence / Profile preview

Protease-Activated Receptor 4 (PAR4)

Target: PAR4
Molecular classification: G protein-coupled receptor, Receptor

Overview

Protease-Activated Receptor 4 (PAR4) is a G protein-coupled receptor activated by proteolytic cleavage, primarily by thrombin. It plays a significant role in platelet activation, hemostasis, inflammation, and cardiovascular physiology, particularly in platelet aggregation and procoagulant activity. It is also implicated in kidney injury and cardiac ischemia-reperfusion injury. Targeting PAR4 offers potential for antithrombotic benefits with reduced bleeding risk.

Other names: F2RL3

Mechanism of action

Antagonism of PAR4 receptor activation by thrombin or other serine proteases, preventing downstream signaling cascades.

Biological functions

Platelet activationHemostasisInflammationSignal transduction

Disease associations

Cardiovascular diseaseThrombosisRenal diseaseInflammation

Safety considerations

Bleeding risk (though potentially lower than with other antithrombotics)

Interacting drugs

Vorapaxar (indirectly, via PAR1)

1 more in the full profile.

Beyond the preview

Go deeper on Protease-Activated Receptor 4 (PAR4).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Protease-Activated Receptor 4 (PAR4).

Explore the full profile