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Target intelligence / Profile preview
Protease Inhibitor (PI)
- Target
- PI
- Molecular classification
- Enzyme Inhibitor
01
Overview
Protease inhibitors are a class of molecules that inhibit the activity of proteases—enzymes responsible for cleaving proteins into smaller, functional units. By blocking these enzymes, protease inhibitors prevent the maturation and replication of viruses or modulate other biological processes involving protein cleavage.
- Other names
- Protease inhibitorsPIs
02
Mechanism of action
Protease inhibitors bind directly to viral or human proteases, blocking their ability to cleave precursor polyproteins or target proteins. This inhibition prevents the formation of functional proteins and halts viral replication or modulates other biological processes.
03
Biological functions
Inhibition of protein cleavageAntiviral activity
04
Disease associations
HIV/AIDSHepatitis CCOVID-19Cancer (potential)Metabolic diseases (potential)
05
Safety considerations
Gastrointestinal disturbancesMetabolic changes (increased cholesterol or blood sugar)Liver toxicityDrug interactions due to cytochrome P450 inhibition
06
Interacting drugs
Ritonavir
3 more in the full profile.
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