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Proteasome 20S Chymotrypsin-like Subunit Beta Type 5 (PSMB5)

Target: PSMB5
Molecular classification: Enzyme

Overview

PSMB5 encodes the proteasome subunit beta type-5, a catalytic component of the 20S core proteasome complex. This protein exhibits chymotrypsin-like activity, cleaving peptide bonds after large hydrophobic residues. The proteasome complex degrades most intracellular proteins in an ATP/ubiquitin-dependent manner via a nonlysosomal pathway and plays essential roles in regulating protein quality control, cell cycle progression, signal transduction, immune responses, and stress responses.

Mechanism of action

Chymotrypsin-like protease inhibition

Biological functions

Protein degradationProtein quality controlCell cycleSignal transductionImmune responseStress response

Disease associations

Neurodegenerative diseaseCancer

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