Proteasome 26S subunit, non-ATPase 4 pseudogene 1 (PSMD4P1)

Proteasome 26S subunit, non-ATPase 4 pseudogene 1 (PSMD4P1) is classified as a pseudogene, meaning it is a genomic DNA sequence similar to a functional gene (in this case, PSMD4, a subunit of the 26S proteasome complex), but it is not capable of coding for a functional protein product[1][4][6]. Pseudogenes like PSMD4P1 may contain sequence elements of their parent gene but typically harbor disabling mutations such as frameshifts or premature stop codons, preventing normal protein expression. In general, PSMD4P1 is not a direct therapeutic target and does not encode a druggable protein or functional enzyme, receptor, or transporter[1][3][4][6]. Although rare pseudogenes may regulate their parent gene’s expression or have RNA-level functions, there is no evidence at present for such a role for PSMD4P1. Key critical notes: - The entry refers to a **pseudogene**, not a functional protein or canonical disease target[1][4][6]. - As a result, it does **not meet criteria for a typical therapeutic target** (no encoded receptor, enzyme, transporter, or druggable protein)[4][6]. - Inclusion as a therapeutic target is **incorrect**; this is a sequence artifact with potential (rare) regulatory roles, but not established for this pseudogene. Summary: - PSMD4P1 is not a real receptor, enzyme, or drug target; it is a noncoding **pseudogene** related to the PSMD4 proteasome subunit, and records explicitly list it as such[1][3][4]. - There are no known drugs, mechanisms of action, biomarker roles, or disease relevance specific to this pseudogene. - This entry should not be included among canonical molecular targets for drug discovery or therapeutic application.

Other names

PSMD4 pseudogene 1proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 pseudogene 1PSMD4P