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Target intelligence / Profile preview
Proteasome 26S Subunit ATPase 4 (PSMC4)
- Target
- PSMC4
- Molecular classification
- AAA+ ATPase, Enzyme
01
Overview
Proteasome 26S subunit ATPase 4 (PSMC4) is a component of the 26S proteasome complex, an ATP-dependent protease responsible for degrading ubiquitinated proteins. It functions as one of six AAA+ ATPases within the regulatory particle of the proteasome, using ATP hydrolysis to unfold and translocate substrate proteins into the core particle for degradation. PSMC4 is involved in protein quality control, cell cycle regulation, and signal transduction. Dysregulation of PSMC4 has been implicated in cancer progression, making it a potential target for anti-cancer therapies.
- Other names
- Rpt3
02
Mechanism of action
Disruption of protein homeostasis
03
Biological functions
Protein quality controlCell cycle regulationDNA repairSignal transductionSubstrate unfoldingSubstrate translocation
04
Disease associations
Cancer
05
Safety considerations
Selectivity for tumor cells
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