Proteasome 26S subunit ATPase 5 (PSMC5)

Proteasome 26S subunit ATPase 5 (PSMC5), also known as 26S proteasome regulatory subunit 8 or SUG1, is an ATPase component of the 19S regulatory particle of the 26S proteasome complex. The 26S proteasome is essential for ubiquitin-dependent protein degradation in eukaryotic cells. PSMC5, a member of the AAA+ ATPase family, is involved in unfolding and translocation of ubiquitinated proteins into the 20S core particle for degradation. It plays key roles in cellular protein quality control, cell cycle regulation, apoptosis, antigen processing for immune presentation, and regulation of transcription through interactions with transcription factors and nuclear receptors. Dysfunction of the proteasome system, including defects in PSMC5, has been implicated in cancer, neurodegenerative diseases, and rare genetic syndromes. While broadly targeted by proteasome inhibitors in cancer therapy, PSMC5 itself has not yet been selectively targeted by small molecules.

Other names

26S proteasome regulatory subunit 8SUG1TRIP1p45/SUGTBP10p45S8RPT626S proteasome AAA-ATPase subunit RPT6Proteasome subunit p45Thyroid hormone receptor-interacting protein 1MSUG1 proteinTat-binding protein homolog 10proteasome (prosome, macropain) 26S subunit, ATPase 5testicular tissue protein Li 149thyroid receptor interactor 1

Proteasome inhibitors bind to and inhibit proteolytic activity, preventing degradation of ubiquitinated proteins, leading to apoptosis especially in rapidly dividing cells