Proteasome 26S subunit ATPase 6 (PSMC6)

Proteasome 26S subunit ATPase 6 (PSMC6) is a key enzymatic component of the 19S regulatory particle of the 26S proteasome complex, a multi-protein complex responsible for ATP-dependent degradation of ubiquitinated proteins within eukaryotic cells. PSMC6 is one of six AAA+ ATPases forming a heterohexameric ring that powers substrate unfolding and translocation into the 20S core particle for proteolysis. The 26S proteasome plays essential roles in maintaining cell function, including regulating the cell cycle, apoptosis, DNA repair, and antigen presentation. Disruption of proteasome function is linked to various human diseases, such as cancer and neurodegenerative disorders, and the proteasome is a recognized drug target in cancer therapy. While drugs such as bortezomib and carfilzomib inhibit the entire 26S proteasome, no approved therapies selectively target PSMC6 itself. Adverse effects associated with proteasome inhibition include cytotoxicity, neurotoxicity, and immune system impairment.

Other names

SUG2p42RPT526S proteasome regulatory subunit 10B26S proteasome AAA-ATPase subunit RPT4proteasome subunit p42HEL-S-73CADP44

Inhibition of proteasome-mediated protein degradation (leading to accumulation of ubiquitinated proteins and apoptosis, especially in rapidly proliferating cells like cancer); Blockage of ATPase function (hypothetical, as no approved drugs directly target PSMC6's ATPase activity)