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Proteasome activator subunit 2 pseudogene 1 (PSME2P1)

Target
PSME2P1
Molecular classification
Other (Pseudogene)
01

Overview

PSME2P1 (Proteasome activator subunit 2 pseudogene 1) is a human pseudogene located on chromosome 8 that is homologous to the functional PSME2 gene, which encodes the beta subunit of the 11S proteasome activator complex (PA28 beta). PSME2P1 itself does **not** encode a functional protein and is classified as a pseudogene. While some pseudogenes may play regulatory roles at the RNA level by acting as microRNA decoys or influencing expression of their parental genes, there is currently no reported evidence of such a function for PSME2P1. Therefore, PSME2P1 is **not considered a receptor, enzyme, transporter, or other classical molecular therapeutic target**, and there are no associated drugs, mechanisms of action, or biomarker information for this pseudogene. If you are seeking information about a functional component of the proteasome, such as the **proteasome activator subunit 2 (PSME2, PA28 beta)**, refer instead to entries for the actual coding gene/protein, not to this pseudogene. **Clarification:** The entry "proteasome activator subunit 2 pseudogene 1" (PSME2P1) is a non-coding pseudogene and **not** a functional gene or protein. It is not a druggable or actionable therapeutic target. If your interest concerns the biologically active PA28 beta subunit, that target is encoded by the PSME2 gene, not by PSME2P1.

Other names
PSME2PProteasome (prosome, macropain) activator subunit 2 pseudogene 1Proteasome activator subunit 2 pseudogene 1
02

Mechanism of action

Not applicable (no known mechanism, as it does not encode a protein).

03

Biological functions

None attributable to the protein level; as a pseudogene, PSME2P1 does not encode a functional protein. However, some pseudogenes can act as microRNA decoys or regulators of related gene expression, though no specific function for PSME2P1 has been described in the literature.
04

Disease associations

None established for PSME2P1. In principle, pseudogenes may contribute to gene regulation or be involved in disease via regulatory RNA mechanisms, but there is no evidence of a role in disease for this specific pseudogene.
05

Safety considerations

None (not a protein or therapeutic target).
06

Interacting drugs

None (as a pseudogene, it is not a drug target)
07

Biomarkers

None described for PSME2P1.

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