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Proteasome activator subunit 3 pseudogene (ENSG00000229808, LOC100422526) is a non-coding DNA sequence homologous to the functional *PSME3* gene, which encodes the proteasome activator subunit 3 (PA28-gamma). Unlike its functional counterpart, this pseudogene does not code for a protein and is not involved in cellular or disease mechanisms. The functionally relevant target in human biology and disease is PA28-gamma, encoded by *PSME3*, which participates in proteasome activation, cell cycle regulation, apoptosis, and cancer progression[1][3][5][7].
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