Proteasome assembly chaperone 3 (PSMG3)

Proteasome assembly chaperone 3 (PSMG3) is a chaperone protein that promotes the assembly of the 20S proteasome, a core component of the ubiquitin-proteasome system responsible for regulated protein degradation in cells. PSMG3 likely interacts with PSMG1-PSMG2 heterodimers to orchestrate the correct and efficient assembly of proteasome complexes. It plays crucial roles in protein homeostasis, cell cycle regulation, and metabolic pathways[1][4][8]. Recent studies show that PSMG3 is highly expressed in various cancers, where it may drive tumor cell proliferation, migration, and poor prognosis. Its function as a proteasome assembly factor implicates it in broad cellular processes and disease mechanisms, particularly in oncogenesis and protein metabolism[2][3]. There are no known drugs directly targeting PSMG3, and the safety and therapeutic challenges remain undetermined in current literature.

Other names

C7orf48PAC3PAC-3hPAC3Pba3Proteasome chaperone homolog 3MGC10911Proteasome assembling chaperone 3