Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Proteasome inhibitor PI31 subunit (PSMF1)
- Target
- PSMF1
- Molecular classification
- Other, Proteasome regulator, Endopeptidase inhibitor
01
Overview
The **Proteasome inhibitor PI31 subunit (PSMF1)** is a regulatory protein that inhibits the activation and proteolytic activity of the 20S proteasome by interacting with its regulatory complexes, PA700 (19S) and PA28 (11S). PSMF1 thereby modulates protein turnover in the cell, particularly in pathways reliant on ubiquitin-mediated degradation. Its function is crucial for maintaining the balance between protein synthesis and degradation, and alterations in PSMF1 have been associated with neurodegenerative disorders such as early-onset Parkinson's disease[1][3][5].
- Other names
- PI31hPI31proteasome inhibitor subunit 1PSMF1PI-31proteasome (prosome, macropain) inhibitor subunit 1proteasome inhibitor hP131 subunit
02
Mechanism of action
Inhibition of proteasome-mediated protein hydrolysis; blocks activation of proteasome by regulatory complexes
03
Biological functions
Regulation of proteasome activityEndopeptidase inhibitionProtein degradation controlInhibition of proteasome activation by regulatory particles (PA700/19S and PA28/11S)
04
Disease associations
Neurodegenerative disease (e.g., Parkinson disease 15, autosomal recessive early-onset)Potential relevance in diseases involving ubiquitin-proteasome system and protein homeostasis
05
Safety considerations
Targeting or inhibiting proteasome regulators could impair essential protein degradation and cellular homeostasis, with risks of unintended cell death or dysfunction
Beyond the preview
Go deeper on Proteasome inhibitor PI31 subunit (PSMF1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Proteasome inhibitor PI31 subunit (PSMF1).