Proteasome maturation protein mRNA (POMP mRNA)

Proteasome maturation protein (POMP) mRNA encodes a vital molecular chaperone required for the biogenesis of the 20S proteasome core particle (UniProt: P50102). By facilitating the assembly of alpha and beta subunits, POMP ensures the functional integrity of the ubiquitin-proteasome system, which is responsible for degrading misfolded or regulatory proteins (PubMed: 26455399). In the context of disease, POMP mRNA expression is often upregulated in various malignancies, such as bladder and colon cancers, to support the high metabolic demands and protein turnover of rapidly dividing cells (PubMed: 26455399). Conversely, mutations in the 5' untranslated region (UTR) of POMP mRNA are linked to KLICK syndrome, a rare skin disorder characterized by impaired proteasome function and altered keratinocyte differentiation (PubMed: 20301638). As a therapeutic target, POMP mRNA is primarily approached using RNA interference (siRNA) or antisense oligonucleotides (ASOs) to deplete POMP levels, thereby inducing proteotoxic stress and apoptosis in cancer cells (PubMed: 26455399). This strategy aims to bypass resistance mechanisms associated with direct proteasome inhibitors like bortezomib by preventing the formation of the proteasome itself. Additionally, the regulation of POMP mRNA is critical in autoinflammatory conditions, where its deficiency leads to the accumulation of ubiquitinated proteins and activation of inflammatory pathways (PubMed: 30397348).

Other names

Proteasome maturation protein transcriptC13orf12 mRNAVoltage-gated K+ channel-modulating protein mRNAUMP1 homolog mRNAhPOMP mRNA

Inhibition of proteasome assembly via RNA interference or antisense-mediated degradation of the POMP transcript to induce proteotoxic stress and apoptosis.