Proteasome subunit alpha 6 pseudogene 1 (PSMA6P1)

Proteasome subunit alpha 6 pseudogene 1 (PSMA6P1) is a genomic DNA sequence in humans that closely resembles, but does not encode, the functional proteasome subunit alpha 6 protein[1][4]. It is considered a pseudogene, meaning it is a nonfunctional segment derived from a gene that once was active. PSMA6P1 is sometimes annotated as PSMA6-LIKE or PSMA6Y, and is separate from the active PSMA6 gene, which encodes a critical component of the 20S core proteasome complex involved in protein degradation. There is no evidence that PSMA6P1 encodes a functional protein, nor is it cataloged as a therapeutic or drug target[1][4]. Key points: - PSMA6P1 is not an active gene or protein, and thus not a conventional drug/receptor target[1][4]. - It should not be confused with PSMA6 (Proteasome subunit alpha type-6), which is an essential proteasome component[2][3][6][7]. - There is no literature indicating a disease association or drug interaction for the pseudogene PSMA6P1. Caution: If you intended to reference the functional proteasome subunit, use Proteasome subunit alpha type-6 (PSMA6), which is a validated target involved in protein homeostasis and is linked to disease and drug mechanisms[2][3][5][6][7].

Other names

PSMA6-LIKEPSMA6YPSMA6P