Proteasome subunit alpha type-6 (PSMA6)

Proteasome subunit alpha type-6 (PSMA6) is a 27 kDa protein encoded by the PSMA6 gene in humans and functions as one of the essential alpha subunits in the 20S core of the proteasome complex[1][3]. The proteasome is a multi-subunit, ATP-dependent protease responsible for the degradation of most intracellular proteins involved in functions such as protein quality control, cell cycle regulation, apoptosis, and antigen presentation[1][3][4]. PSMA6 forms part of the α-rings that constitute the entrances to the proteolytic chamber and control access of substrate proteins for degradation[1][4]. Dysregulation or mutation in PSMA6 and the proteasome machinery is implicated in cancer, cardiovascular, autoimmune, and neurodegenerative diseases. PSMA6 is targeted indirectly by proteasome inhibitors such as bortezomib, which are used in the treatment of multiple myeloma and other malignancies[3][4].

Other names

Proteasome 20S subunit alpha 6Proteasome subunit alpha-120S proteasome subunit alpha-1PROS27p27KIOTAMacropain iota chainMulticatalytic endopeptidase complex iota chainProteasome iota chainProteasome subunit alpha1Proteasome subunit iotaTesticular secretory protein Li 44MGC22756MGC2333MGC2384627 kDa prosomal protein

Proteasome inhibition leads to the accumulation of ubiquitinated and misfolded proteins, inducing cell cycle arrest and apoptosis (especially in rapidly proliferating cancer cells) Disrupts normal degradation of regulatory proteins, affecting cell signaling and immune response