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Target intelligence / Profile preview
Proteasome subunit alpha type-7 (PSMA7)
- Target
- PSMA7
- Molecular classification
- Peptidase T1A family, Proteasome subunit
01
Overview
Proteasome subunit alpha type-7 (PSMA7) is a core component of the 20S proteasome complex, which is essential for the ATP/ubiquitin-dependent degradation of most intracellular proteins in eukaryotic cells. It plays a central role in protein quality control, antigen processing, and regulation of cellular pathways, including those involving HIF-1α and NOD1. PSMA7's role in tumor growth and its interactions with viral proteins suggest its involvement in disease mechanisms. Overexpression has been linked to colorectal cancer progression and liver metastasis.
- Other names
- 20S proteasome subunit alpha-4alpha4
02
Mechanism of action
Inhibition of proteasome activity, modulation of HIF-1α levels, modulation of NOD1 signaling
03
Biological functions
Protein degradationAntigen processingRegulation of cellular pathwaysRegulation of hypoxia-inducible factor 1-alpha (HIF-1α)Regulation of NOD1-mediated apoptosisRegulation of NF-kB activation
04
Disease associations
Cancer
05
Safety considerations
Ubiquitous expression necessitates careful consideration of off-target effects.
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