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26S Proteasome (β1-Subunit) (None)
- Target
- None
- Molecular classification
- Enzyme, Protease, Proteasome subunit
01
Overview
The 26S proteasome is a large, ATP-dependent multi-protein complex responsible for the regulated degradation of ubiquitinated proteins in eukaryotic cells. The β1-subunit, also known as PSMB1, possesses caspase-like peptidyl-glutamyl peptide-hydrolyzing activity within the 20S core particle. It is a key component of protein quality control and regulation of various cellular processes. Inhibition of the proteasome, including the β1 subunit, is a therapeutic strategy in diseases like multiple myeloma.
- Other names
- Proteasome subunit beta type-1PSMB1LMP2
02
Mechanism of action
Inhibition of proteasome activity; specifically caspase-like activity of the beta-1 subunit.
03
Biological functions
Protein degradationProtein quality controlAntigen processingRegulation of cell cycleRegulation of DNA repairRegulation of transcriptionRegulation of stress responsePeptide hydrolysis
04
Disease associations
CancerInflammationNeurodegenerative diseaseInfectionAutoimmune diseases
05
Safety considerations
Peripheral neuropathyThrombocytopeniaCardiotoxicityImmunosuppression
06
Interacting drugs
Bortezomib
3 more in the full profile.
07
Biomarkers
Expression levels of proteasome subunitsUbiquitinated protein levelsChanges in substrate protein levels
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