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Target intelligence / Profile preview
Proteasome Subunit Beta Type-2 (PSMB2)
- Target
- PSMB2
- Molecular classification
- Proteasome subunit, Non-catalytic protein
01
Overview
Proteasome subunit beta type-2 is a non-catalytic component of the 20S core proteasome complex, essential for regulated degradation of intracellular proteins. It contributes structurally to the active site environment within the proteasome, playing a role in protein quality control and various cellular processes like cell cycle, signal transduction, immune responses, and apoptosis. While PSMB2 itself lacks direct catalytic activity, it is crucial for proper proteasome assembly and function.
- Other names
- 20S proteasome subunit beta-4Macropain subunit C7-IMulticatalytic endopeptidase complex subunit C7-IProteasome component C7-I
02
Mechanism of action
Not applicable (non-catalytic subunit)
03
Biological functions
Protein degradationProtein homeostasisAntigen processingCell cycle regulationSignal transductionImmune responseApoptosisStress response
04
Disease associations
CancerInflammationNeurodegenerative disease
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