Proteasome subunit beta type-4 (PSMB4)

Proteasome subunit beta type-4 (PSMB4) is a protein encoded by the PSMB4 gene, incorporated into the 20S core of the proteasome complex. As one of 28 subunits, it is critical for the assembly and stability of the proteasome, a multicatalytic proteinase complex responsible for ATP/ubiquitin-dependent degradation of damaged or regulatory proteins in a non-lysosomal pathway. While PSMB4 itself is non-catalytic, its role in forming the proteolytic chamber is essential for the complex's function. Dysregulation of the proteasome system, including PSMB4, is implicated in various pathological states, including cancer, neurodegenerative diseases, cardiac conditions, and inflammation. Therapeutically, the proteasome serves as a validated drug target, particularly in oncology, and circulating proteasome components are emerging as potential disease biomarkers

Other names

Proteasome 20S subunit beta 4Proteasome subunit beta-7PROS26HsBPROS26PROS-26HsN3beta-7HN326 kDa prosomal proteinMacropain beta chainMulticatalytic endopeptidase complex beta chainProteasome beta chainProteasome chain 3Testis tissue sperm-binding protein Li 79P

Proteasome inhibition (blocking proteolytic activity disrupts protein degradation, leading to cell cycle arrest and apoptosis, especially in cancer cells)