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Proteasome Subunit Beta Type-5 (PSMB5)
- Target
- PSMB5
- Molecular classification
- Enzyme, Protease, Threonine-type endopeptidase, Proteasome Subunit
01
Overview
Proteasome subunit beta type-5 (PSMB5) is a catalytic subunit of the 20S core proteasome complex, essential for intracellular protein degradation. It possesses chymotrypsin-like activity, cleaving peptide bonds after hydrophobic amino acid residues. PSMB5 plays a crucial role in maintaining cellular protein homeostasis and is implicated in various diseases, including cancer, neurodegeneration, and autoimmune disorders. It is a validated drug target, with inhibitors like bortezomib and carfilzomib used in multiple myeloma treatment. Drug resistance can arise from mutations or overexpression of PSMB5.
- Other names
- 20S proteasome subunit beta-5
02
Mechanism of action
Inhibition of chymotrypsin-like activity of the proteasome
03
Biological functions
Protein degradationCell cycle regulationAntigen processingImmune responseProtein homeostasisRegulation of gene transcriptionApoptosisSignal transduction
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular diseaseInflammatory/autoimmune disordersDrug resistance
05
Safety considerations
Drug resistance due to mutations or overexpressionPotential for off-target effects due to the broad role of the proteasome
06
Interacting drugs
Bortezomib
1 more in the full profile.
07
Biomarkers
PSMB5 expression levels (for prognosis in some cancers)
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