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Target intelligence / Profile preview
Large multifunctional peptidase 7 (LMP7)
- Target
- LMP7
- Molecular classification
- Enzyme, Protease, Proteasome B-type family, T1B family, Proteasome subunit
01
Overview
Large multifunctional peptidase 7 (LMP7/PSMB8/Beta5i) is an inducible catalytic component of the immunoproteasome critical for immune surveillance via antigen processing. Its selective inhibition represents a promising strategy against certain cancers such as multiple myeloma while also playing roles in autoimmunity due to its central function in shaping peptide repertoires presented on MHC class I molecules.
- Other names
- PSMB8Beta5iProteasome subunit beta type-820S proteasome subunit beta-5iImmunoproteasome subunit β5i
02
Mechanism of action
Selective inhibition of LMP7 activity, suppression of ubiquitinated protein turnover, induction of apoptosis
03
Biological functions
Antigen processing for MHC-I presentationProtein degradationProtein quality controlImmune response
04
Disease associations
AutoimmunityInflammationCancerMultiple myeloma
05
Interacting drugs
M3258
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