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Target intelligence / Profile preview
Proteasome Subunit Beta Type-9 (PSMB9)
- Target
- PSMB9
- Molecular classification
- Enzyme, Protease, Proteasome subunit
01
Overview
Proteasome subunit beta type-9 (PSMB9), also known as 20S proteasome subunit beta-1i or LMP2, is a protein encoded by the PSMB9 gene in humans. It is a catalytic subunit of the immunoproteasome, a specialized form of the proteasome complex involved in immune function. PSMB9 exhibits chymotrypsin-like endopeptidase activity and is essential for generating peptides presented on MHC class I molecules to cytotoxic T cells. Its expression is induced by interferon-gamma and its function is crucial for immune surveillance and cellular adaptation to stress.
- Other names
- 20S proteasome subunit beta-1iLMP2β1iRING12MC7
02
Mechanism of action
Proteasome inhibition
03
Biological functions
Antigen processingProtein degradationImmune responseChymotrypsin-like endopeptidase activity
04
Disease associations
Autoimmune diseasesCancerInflammation
05
Safety considerations
Potential for immune-related adverse eventsOff-target effects due to proteasome involvement in multiple cellular processes
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