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Target intelligence / Profile preview
Protein 50S Ribosomal Subunit (50S)
- Target
- 50S
- Molecular classification
- Ribosomal Subunit, RNA-Protein Complex
01
Overview
The 50S ribosomal subunit is the larger component of the prokaryotic (bacterial and archaeal) 70S ribosome. It plays a central role in protein synthesis by catalyzing peptide bond formation, facilitating translation of messenger RNA (mRNA) into polypeptides, and providing binding sites for transfer RNAs (tRNAs) and various protein factors. Many antibiotics bind specifically to sites on or near the functional centers of the bacterial/archaeal 50S ribosomal subunit, inhibiting key steps in translation.
02
Mechanism of action
Inhibition of protein synthesis by binding to the 50S ribosomal subunit and interfering with peptide bond formation or translocation.
03
Biological functions
Protein synthesisPeptide bond formationmRNA translationtRNA binding
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistanceOff-target effects in eukaryotes (mitochondria)
06
Interacting drugs
Macrolides
3 more in the full profile.
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