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Protein Aggregation (N/A)
- Target
- N/A
- Molecular classification
- Process, Conformational change
01
Overview
Protein aggregation is a molecular phenomenon where proteins, particularly misfolded or intrinsically disordered ones, accumulate and clump together. This can lead to the formation of amorphous aggregates, oligomers, and amyloid fibrils. It is closely linked with numerous diseases, including many neurodegenerative disorders, due to the disruption of cellular processes and proteostasis. Aggregation can be triggered by mutations, environmental stressors, and post-translational modifications, destabilizing native protein conformations and exposing hydrophobic regions. In biopharmaceutical production, protein aggregation affects drug safety and efficacy.
- Other names
- Protein misfoldingAmyloid formationOligomerization
02
Mechanism of action
N/A
03
Biological functions
Protein misfoldingProtein aggregationDisruption of proteostasis
04
Disease associations
Alzheimer's diseaseParkinson's diseaseHuntington's diseaseAmyotrophic lateral sclerosis (ALS)Prion diseasesCystic fibrosisSickle cell anemiaNeurodegenerative diseaseProtein conformational diseases
05
Safety considerations
Immunogenicity of aggregatesOff-target effects of aggregation inhibitors
06
Biomarkers
Aggregated protein levels in CSFAmyloid plaques in brain imaging
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