Protein angel homolog 2 (ANGEL2)

Protein angel homolog 2 (ANGEL2) is a divergent member of the CCR4 family of deadenylases, functioning as an RNA phosphatase rather than a traditional deadenylase. ANGEL2 catalyzes the conversion of 2′,3′-cyclic phosphates on RNA molecules into 2′,3′-hydroxyl groups, a reaction required for proper tRNA maturation, recycling during cellular stress, and the unconventional splicing of select mRNAs such as X-box binding protein 1 (XBP1). Rather than shortening poly(A) tails like classical deadenylases, ANGEL2 specializes in preparing RNA ends for ligation and maturation. This activity supports essential RNA processing functions in both the mitochondrion and cytoplasm. Epigenetic dysregulation of ANGEL2 has been implicated as a biomarker in cervical carcinogenesis, highlighting its clinical relevance despite the absence of direct drug interactions or therapeutic targeting at present.

Other names

CCR4DKIAA0759LFLJ12793Ccr4dangel homolog 2 (Drosophila)protein angel homolog 2