Protein Arginine Methyltransferase 1 (PRMT1)

Protein arginine methyltransferase 1 (PRMT1) is the predominant type I protein arginine methyltransferase in mammals. It catalyzes the transfer of methyl groups from S-adenosyl-L-methionine (SAM) to the guanidino nitrogens of arginine residues in target proteins, resulting in monomethylation and asymmetric dimethylation. This post-translational modification plays a crucial role in regulating gene expression, chromatin remodeling, signal transduction, RNA processing, and other cellular processes. Dysregulation of PRMT1 has been implicated in various human diseases including cancer, making it a therapeutic target.

Other names

Protein arginine N-methyltransferase 1Interferon receptor 1-bound protein 4IR1B4Histone–arginine N-methyltransferase PRMT1HRMTL12HMT2

Inhibition of protein arginine methylation