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Target intelligence / Profile preview
Protein Arginine Methyltransferase 5 (PRMT5)
- Target
- PRMT5
- Molecular classification
- Enzyme, Protein Arginine Methyltransferase, Histone modification
01
Overview
PRMT5 is a type II protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine residues on both histone and non-histone proteins. It plays a critical role in transcriptional regulation, RNA splicing, ribosome biogenesis, DNA repair, cell cycle progression and proliferation, embryonic development, and stem cell pluripotency maintenance. Overexpression or dysregulation of PRMT5 has been linked to various cancers.
- Other names
- Histone-arginine N-methyltransferaseJak-binding protein 1 (Jbp1)HRMT1L5
02
Mechanism of action
Small molecule inhibitors targeting catalytic activity or protein-protein interactions (e.g., PRMT5-MEP50)
03
Biological functions
Transcriptional regulationGene silencingRNA splicingRibosome biogenesisDNA repairCell cycle progressionCell proliferationEmbryonic developmentStem cell pluripotency maintenance
04
Disease associations
Cancer
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