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Target intelligence / Profile preview
Protein-arginine N-methyltransferase 3 (PRMT3)
- Target
- PRMT3
- Molecular classification
- Enzyme, Protein Arginine Methyltransferase
01
Overview
PRMT3 is an enzyme that catalyzes the methylation of guanidino nitrogens on arginine residues in proteins. It performs both monomethylation and asymmetric dimethylation, classifying it as a type I protein arginine methyltransferase. Its primary substrate is the 40S ribosomal protein S2 (RPS2). It plays roles in ribosome biogenesis, post-translational modification, and gene expression regulation. Altered expression or activity has been associated with cancer progression and chemoresistance mechanisms.
02
Mechanism of action
Methylates arginine residues on proteins, influencing their function and interactions.
03
Biological functions
Ribosome biogenesisPost-translational modificationGene expression regulation
04
Disease associations
CancerChemoresistance
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