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Protein associated with LIN7 2, MAGUK p55 family member (PALS2)
- Target
- PALS2
- Molecular classification
- Membrane-associated guanylate kinase (MAGUK) family, p55-like MAGUK subfamily, Peripheral membrane protein
01
Overview
Protein associated with LIN7 2, MAGUK p55 family member (PALS2) is a member of the membrane-associated guanylate kinase (MAGUK) family, specifically the p55-like subfamily. PALS2 is a peripheral membrane protein thought to function in tumor suppression and receptor clustering by forming multiprotein complexes with transmembrane, cytoskeletal, and cytoplasmic signaling proteins. Although linked to certain neural and sensory disorders, there is currently no established role for PALS2 as a direct therapeutic target or biomarker[1][2][5][6].
- Other names
- PALS2MPP6VAM1VAM-1p55TMembrane protein, palmitoylated 6Protein associated with LIN7 2, MAGUK p55 family memberMAGUK p55 subfamily member 6Veli-associated MAGUK 1MAGUK protein p55TMembrane palmitoylated protein 6
02
Biological functions
Tumor suppressionReceptor clusteringFormation of multiprotein complexesMaintenance of postsynaptic density structure (predicted in animal models)
03
Disease associations
PolyneuropathyHearing lossAtaxiaRetinitis pigmentosaCataract
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