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Protein atonal homolog 1 (ATOH1)
- Target
- ATOH1
- Molecular classification
- Transcription factor, Basic helix-loop-helix (bHLH) transcription factor, Class II bHLH transcription factor
01
Overview
ATOH1 is a sequence-specific DNA-binding transcription activator essential for the development and differentiation of multiple cell types. It functions as a tumor suppressor gene and is involved in several signaling pathways including Notch/gamma-secretase, Wnt, SHH, TGF-beta, and JNK/MAPK.
- Other names
- Hath1Math1MATH-1bHLHa14Helix-loop-helix protein mATH-1
02
Mechanism of action
Activation of the Jun N-terminal kinase (JNK) pathway
03
Biological functions
Cell fate determinationCell differentiationRegulation of proliferationRegulation of apoptosisE-box dependent gene expressionTumor suppressor
04
Disease associations
CancerColorectal cancerMerkel cell carcinomaDeafness
05
Interacting drugs
Notch/gamma-secretase inhibitors
06
Biomarkers
ATOH1 expression (predictive biomarker for Notch/gamma-secretase inhibitor response)
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