Protein bicaudal D homolog 2 (BICD2)

Protein bicaudal D homolog 2 (BICD2) is a conserved coiled-coil cargo adaptor protein involved in intracellular transport. It functions primarily by binding and activating the dynein-dynactin motor complex, facilitating minus-end-directed transport along microtubules. BICD2 couples dynein to a variety of cargos—including Golgi-derived vesicles and synaptic vesicles—by interacting via its C-terminal domain with cargo proteins such as the GTPase Rab6. In neurons, BICD2 is crucial for the proper transport of synaptic vesicles. Mutations in BICD2 are associated with autosomal dominant spinal muscular atrophy with lower extremity predominance (SMA-LED), manifesting as lower limb muscle weakness and atrophy[4][1][2][3]. BICD2 is not a typical pharmacological target such as an enzyme or receptor, and no known drugs currently act directly on this protein.

Other names

BICD2BICD cargo adaptor 2KIAA0699Bic-D 2SMALED2SMALED2ASMALED2BbA526D8.1coiled-coil protein BICD2cytoskeleton-like bicaudal D protein homolog 2homolog of Drosophila bicaudal D