Protein Carbamoylation

Protein carbamoylation is a non-enzymatic post-translational modification where a carbamoyl group is covalently added to proteins, primarily at the N-terminal amino group or the ε-amino group of lysine residues. This process occurs via reaction with isocyanic acid, which can be generated from urea breakdown or through myeloperoxidase-mediated oxidation of thiocyanate during inflammation. Carbamoylation alters protein structure and function, often leading to impaired protein/enzyme activity, changes in gene expression and cell signaling, and disruption of metabolic pathways. It is associated with molecular aging and pathological conditions like chronic kidney disease and cardiovascular disease.

Other names

CarbamylationProtein carbamylation/carbamylation