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Target intelligence / Profile preview
Protein Carbamylation
- Molecular classification
- Post-translational modification
01
Overview
Protein carbamylation is a nonenzymatic post-translational modification involving the covalent binding of isocyanic acid to proteins, primarily at N-terminal α-amino groups and lysine ε-amino groups, forming homocitrulline. This modification alters protein structure and function, contributing to aging and disease processes, notably in chronic kidney disease, atherosclerosis, and inflammatory conditions. Carbamylation serves as a biomarker for disease progression and can impact protein-protein interactions and cellular clearance mechanisms.
- Other names
- Protein modification by isocyanic acidHomocitrullination
02
Biological functions
Protein structure alterationProtein function alterationMolecular aging
03
Disease associations
Chronic kidney diseaseAtherosclerosisSystemic inflammationCardiovascular disease
04
Safety considerations
Artifactual carbamylation during sample preparationPotential for altered protein function and immunogenicity
05
Biomarkers
Homocitrulline levelsCarbamylated protein levels
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